How Big is Big Enough?
Christof A. Bertram, Marc Aubreville, Christian Marzahl, Andreas Maier, Robert Klopfleisch
Quantification of mitotic figures (MF) within the tumor areas of highest mitotic density is the most important prognostic parameter for outcome assessment of many tumor types. However, high intra- and inter-rater variability results from diffculties in individual MF identification and region of interest (ROI) selection due to uneven MF distribution. Deep learning-based algorithms for MF detection and ROI selection are very promising methods to overcome these limitations.
Schlüsselwörter: mitotic figures, MF, ROI